Pr. Marzieh Salehi
San Antonio,
United States of America
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Rerouting the gut and entero-pancreatic axis

Diabetes remission after gastric bypass surgery (GB) is reported shortly after surgery before any significant weight loss has occurred. The weight-loss independent glycemic effects of gastric bypass are characterized by prandial short-lived hyperinsulinemia as a result of β-cell stimulation by glucose and incretins. Despite improved glycemia and enhanced meal-induced insulin and GLP-1 response after GB, and to lesser extent after sleeve gastrectomy (SG), prandial glucagon levels are also reported to be exaggerated after these procedures. The relative role of altered β- and α-cell secretory response in glycemic control after GB or SG remains to be determined. However, evidence suggest that both hormonal and non-hormonal components of enteroinsular axis activity play a role in changes in islet-cell secretory response to meal ingestion after GB.

Short biography

Marzieh Salehi, MD MS FACP
Associate Professor of Medicine
Department of Medicine, Diabetes Division
UT Health at San Antonio
SVTHCS, Medical Director, Bartter Research Unit, Audie Murphy Hospital

Dr. Salehi is a board-certified endocrinologist with expertise as a clinician, translational investigator and educator in obesity and diabetes. She has been nationally recognized as clinician expert in glucose abnormalities, such as hypoglycemia, after bariatric surgery which has been one of the areas of her research and continuously funded by National Institute of Health, American Heart Association, and American Society of Metabolic and Bariatric Surgery. The focus of her research is studying the role of gut-brain-pancreas axis on glucose metabolism and energy balance mediated by hormonal and neural factors derived from the gut.